New Insight into the Antithrombotic Mech

New Insight into the Antithrombotic Mechanism of Berberine: The Wisdom of Natural Drugs in Gut Microbiota Metabolism

 

A breakthrough in the mechanism of berberine, a natural drug, in antithrombosis has been achieved. This study reveals for the first time that berberine exerts its antithrombotic effect by reshaping the gut microbiota. It can promote the gut microbiota to accelerate the degradation of the harmful metabolite "phenylacetic acid", thereby reducing the production of the prothrombotic substance "phenylacetylglycine" and blocking the pathway of thrombus formation from the metabolic source.

 

This discovery closely links the mechanism of action of natural drugs with the gut microbiota metabolic network, demonstrating the unique value of berberine in the field of antithrombosis. It is no longer a simple component effect, but achieves thrombus prevention at the metabolic level by regulating the intestinal microecology, opening up a new perspective for the research of natural drugs.

 

For the prevention and treatment of thrombotic diseases, the clarification of this mechanism is of great significance. It suggests that in the future, more precise thrombus prevention and treatment strategies may be developed from the perspective of gut microbiota regulation and metabolite intervention. As a representative of natural drugs, berberine is also expected to play an important role in this, bringing safer and more targeted treatment options for patients.