Suno Free Music Usage Guide: Understand

Suno Free Music Usage Guide: Understand Quotas and Rules in One Article

 

Want to try AI-generated music but worried about high costs? As a popular AI music generation tool, Suno's free benefits have always been a focus for users. Today, we'll break down the key information about Suno's free version in detail to help you clearly understand the boundaries and rules of its "free" service.

 

First, the clear answer: Suno does offer free music services, but there are usage quotas—It is not completely unlimited. In terms of specific quotas, free users automatically get 50 credits every day, and generating one complete song consumes 10 credits. Calculated this way, free users can create a maximum of 5 music tracks per day. The quota resets at a fixed time every day, which is more than enough to meet needs like daily trials and small-scale creations.

 

Beyond quota limits, there are key usage rules to note for free-version music: Free-generated music is limited to non-commercial scenarios, such as personal creative hobbies, background music for family gatherings, and soundtracks for non-profit short videos. It cannot be used for profit-making activities like advertisements, paid courses, or commercial promotions. At the same time, when using free music, you must clearly label it with "Made With Suno" to respect the tool's copyright ownership and avoid infringement risks.

 

For beginners new to AI music generation, Suno's free quota allows you to experience the convenience of AI creation at no cost, while also helping you familiarize yourself with the operation logic through a limited number of attempts. If you later have higher-frequency creation needs (such as generating more than 5 tracks per day) or need to use the music for commercial purposes, you can consider upgrading to the paid version and choose a service plan that better fits your needs.

El código de longevidad de una supercent

El código de longevidad de una supercentenaria de 117 años: la investigación científica revela la verdad sobre genes, hábitos y envejecimiento

 

En agosto de 2024, María Branyas, la mujer más longeva del mundo con 117 años, falleció tranquilamente en Olot, España. Vivió más de 30 años más que la esperanza de vida promedio de las mujeres en la región (alrededor de 86 años) y no padeció cáncer ni enfermedad de Alzheimer, solo una leve pérdida auditiva y deterioro de la movilidad. Antes de su muerte, el equipo de Manel Esteller del Instituto de Investigación en Leucemia Josep Carreras de Barcelona realizó un análisis multiómico completo (que abarcó genómica, proteómica, epigenómica, metabolómica y microbioma) sobre muestras de su sangre, saliva, orina y heces, recolectadas mediante técnicas mínimamente invasivas. Al comparar los resultados con los de poblaciones no supercentenarias, el equipo buscó desvelar los secretos de su "longevidad sin enfermedades". Este análisis es el estudio más exhaustivo realizado hasta la fecha sobre una supercentenaria (persona de ≥110 años) —un grupo tan raro que solo aproximadamente 1 de cada 6 millones de personas en el mundo pertenece a él, lo que convierte la trayectoria vital de María en una muestra invaluable para la investigación de la biología del envejecimiento.

 

Cuando se habla de envejecimiento, muchas personas asocian la longevidad con telómeros más largos —las "gorras protectoras" en los extremos de los cromosomas que se acortan naturalmente con la edad, y los telómeros anormalmente cortos suelen estar relacionados con enfermedades asociadas a la edad. Sin embargo, los resultados de las pruebas de María desafiaron esta percepción: la longitud promedio de sus telómeros era menor que la de todos los voluntarios sanos, incluso alcanzando un estado de "acortamiento extremo". Lo más inusual fue que este acortamiento extremo de los telómeros no la expuso a enfermedades —no padeció enfermedades relacionadas con la edad como el cáncer o la enfermedad de Alzheimer hasta el final de su vida, solo una leve pérdida auditiva y problemas de movilidad. El equipo de investigación especula que esta "ventaja de telómeros cortos" podría haber contribuido a su longevidad sin cáncer: los telómeros excesivamente cortos limitan la proliferación ilimitada de células malignas, reduciendo fundamentalmente el riesgo de cáncer. Este hallazgo rompe la creencia inherente de que "telómeros más largos significan mayor longevidad", demostrando que el acortamiento de los telómeros es solo un "marcador del reloj" del envejecimiento, no un "culpable directo" de las enfermedades. Una "paradoja del envejecimiento" similar se ha observado en otras supercentenarias. Por ejemplo, entre 32 supercentenarias de 110 a 119 años estudiadas por la Universidad de Boston, a pesar de mostrar signos de envejecimiento como el acortamiento de telómeros y la senescencia de células inmunes, solo 2 (6%) tenían antecedentes de infarto de miocardio, 4 (13%) habían sufrido un derrame cerebral y 8 (25%) tenían antecedentes de cáncer (todos curados). Estas cifras son mucho mejores que las de la población promedio de 70 años, que tiene una tasa de infarto de miocardio del 15%, tasa de derrame cerebral del 20% e incidencia de cáncer superior al 40%. Claramente, la longevidad de las supercentenarias no significa "no envejecer", sino "separación entre envejecimiento y enfermedad".

 

El análisis multiómico de María reveló que su cuerpo presentaba simultáneamente "señales de envejecimiento" y "mecanismos protectores" —una característica común entre las supercentenarias de todo el mundo. En términos de señales de envejecimiento, su sistema inmunológico mostraba "señales de senescencia": aumentaba la actividad de células inmunes relacionadas con la inflamación y se expandía anormalmente la población de linfocitos B (un signo común de deterioro inmunológico en los ancianos). Sin embargo, una serie de "características protectoras" construyeron una barrera de salud para ella. La secuenciación del genoma completo descubrió que portaba múltiples "variantes genéticas anti-envejecimiento": la variante DSCAML1 mejora la capacidad de las células inmunes para reconocer células anormales y protege las células nerviosas para mantener la cognición; las variantes LRP1/2 promueven la eliminación de colesterol excesivo y proteínas amiloides en la sangre, previniendo la esclerosis vascular y la demencia. Más importante aún, no tenía variantes dañinas asociadas a enfermedades como la enfermedad de Alzheimer o la diabetes. Un estudio publicado en la revista italiana GeroScience también confirmó que el 82% de las supercentenarias portan al menos una variante genética que protege contra enfermedades cardiovasculares o apoya el sistema inmunológico, y su tasa de portación del alelo APOEε4 (un gen de riesgo para la enfermedad de Alzheimer) es 0 —mucho menor que el 15% de la población general. Además, la eficiencia de su metabolismo lipídico era comparable a la de una persona de mediana edad: su colesterol de lipoproteínas de alta densidad (HDL-C, "colesterol bueno") alcanzaba los 72 mg/dl (el estándar saludable para mujeres es >50 mg/dl), y su colesterol de lipoproteínas de muy baja densidad (VLDL-C) era solo de 6 mg/dl, lo que permitía la eliminación eficiente de lípidos que dañan los vasos sanguíneos. Su nivel de inflamación también estaba en un "estado joven": el marcador inflamatorio GlycA era de 621 μmol/l (un valor <650 μmol/l se considera saludable), mientras que el 70% de los ancianos promedio tienen niveles elevados de GlycA, y solo el 13% de la cohorte de 32 supercentenarias tenía niveles anormales. Este estado de baja inflamación le permitió superar con éxito la COVID-19 a los 113 años, convirtiéndola en la superviviente de COVID-19 más mayor de España. Su microbioma intestinal también mostraba características "juveniles": el contenido de bifidobacterias (una bacteria clave para mantener el equilibrio inmunológico intestinal) era tres veces mayor que el de los ancianos promedio, mientras que el clostridio proinflamatorio se reducía significativamente. Esta característica también se observa en las supercentenarias italianas; los estudios han confirmado que las bifidobacterias inhiben la inflamación al producir ácidos grasos de cadena corta y regulan la inmunidad sistémica, lo que las convierte en un factor clave para la "baja incidencia de enfermedades" en las supercentenarias.

 

Según la evaluación del reloj de metilación del ADNr, la edad biológica de María era 23 años menor que su edad cronológica. Casualmente, en otro estudio, la edad epigenética promedio de 184 centenarios/supercentenarias era 18 años menor que su edad real, y la diferencia de edad generalmente superaba los 20 años en personas de 110 años o más. La clave de este "ralentización del reloj" radica en la alta metilación de secuencias repetitivas de ADN (como LINE-1 y ALU), ya que los niveles estables de metilación previenen la inestabilidad genómica. Por el contrario, la metilación de tales secuencias en los ancianos promedio disminuye significativamente con la edad, acelerando directamente la senescencia celular. El equipo de Manel Esteller también descubrió que el nivel de metilación de la histona H3K79 de María era un 40% más alto que el de un anciano promedio de 70 años —esta modificación mantiene la estructura relajada del ADN, garantizando la expresión normal de genes de reparación celular. Además, el estado de metilación del ADN ribosomal (ADNr) se mantuvo estable, evitando la aceleración de la senescencia celular causada por una función ribosomal anormal. Estas características epigenéticas actúan como "válvulas de ralentización" para las células, haciendo que la tasa de envejecimiento de sus funciones corporales sea mucho menor que su edad cronológica.

 

Aunque los genes y la epigenética sentaron las bases para la longevidad de María, sus hábitos de vida amplificaron aún más estas ventajas —y estos hábitos son muy consistentes entre las supercentenarias de todo el mundo. Mantuvo el hábito de beber 3 tazas de yogur al día durante casi 50 años; cada taza contenía Streptococcus thermophilus y Lactobacillus delbrueckii subsp. bulgaricus, probióticos que nutren los altos niveles de bifidobacterias en su intestino. Un estudio italiano sobre supercentenarias descubrió que el 70% de ellas consume alimentos fermentados al menos 5 veces a la semana, lo que resulta en una proporción significativamente mayor de bacterias beneficiosas en el intestino en comparación con la población general. Para las personas ordinarias, no es necesario imitar la rutina de "3 tazas al día": consumir 1 taza de yogur con probióticos activos, una pequeña porción de natto o kimchi diariamente durante 3 meses puede aumentar la proporción de bacterias beneficiosas en el intestino en un 20%-30% y reducir los niveles de inflamación en un 10%-15%. Su dieta diaria se centraba en vegetales, pescado, aceite de oliva y granos enteros, con un consumo mínimo de alimentos procesados altos en azúcar y grasas. Entre la cohorte de 32 supercentenarias estudiada en EE.UU., el 68% mantenía una dieta similar; quienes comían pescado de aguas profundas (rico en ácidos grasos Omega-3) al menos 3 veces a la semana tenían niveles de HDL-C 12 mg/dl más altos que quienes no lo hacían. Este patrón dietético optimiza el metabolismo lipídico y reduce el daño a los vasos sanguíneos —para la población general, adherirse a él durante 5 años puede reducir el riesgo de enfermedades cardiovasculares en un 25%. La interacción social regular y una mentalidad positiva también fueron indispensables. María participó en actividades manuales comunitarias incluso después de cumplir 100 años, charlaba por video con su familia todos los días y podía recordar claramente detalles de su mudanza de San Francisco a España cuando tenía 8 años. Esto coincide con los hallazgos de un estudio publicado en la revista Brain, Behavior, & Immunity - Health, que analizó a 2.117 adultos y descubrió que la "ventaja social acumulada" (relaciones familiares, participación comunitaria, apoyo emocional) ralentiza significativamente el envejecimiento epigenético, reduciendo el reloj DunedinPACE (un indicador dinámico de la tasa de envejecimiento) en un 12%. Entre las supercentenarias italianas, el 85% mantiene interacciones sociales al menos 3 veces a la semana, y sus niveles de cortisol son un 15%-20% más bajos que los de quienes tienen poca interacción social. Los niveles excesivamente altos de cortisol aceleran la metilación anormal del ADN, llevando a un envejecimiento más rápido.

 

La investigación confirma que la edad avanzada y la mala salud no están inevitablemente ligadas —el envejecimiento y la enfermedad pueden distinguirse a nivel molecular. Para las personas ordinarias, no es necesario depender de la "suerte genética"; los hábitos de María de comer yogur, seguir una dieta mediterránea y mantener interacciones sociales regulares son todas elecciones replicables. En el futuro, a medida que se amplíen los bancos de muestras de supercentenarias y se profundice la investigación sobre los mecanismos del envejecimiento, las intervenciones anti-envejecimiento dirigidas podrían convertirse en realidad. Sin embargo, el camino hacia la longevidad saludable ya está claro: acumular "capital anti-envejecimiento" a través de pequeñas acciones diarias como una alimentación saludable y la interacción social, y esforzarse por el objetivo final de "vivir de manera independiente y feliz más allá de los 100 años".

The Longevity Code of a 117-Year-Old Sup

The Longevity Code of a 117-Year-Old Supercentenarian: Scientific Research Reveals the Truth About Genes, Habits, and Aging

 

In August 2024, María Branyas, the world's longest-lived woman at 117, passed away peacefully in Olot, Spain. She lived over 30 years longer than the average life expectancy of women in the region (around 86 years) and remained free of cancer and Alzheimer's disease, with only mild hearing loss and mobility impairment. Before her death, Manel Esteller's team from the Josep Carreras Leukemia Research Institute in Barcelona conducted a comprehensive multi-omics analysis (covering genomics, proteomics, epigenomics, metabolomics, and microbiomics) on samples of her blood, saliva, urine, and feces collected via minimally invasive techniques. By comparing the results with those from non-supercentenarian populations, the team aimed to unlock the secrets of her "disease-free longevity." This analysis stands as the most thorough study of a supercentenarian (aged ≥110) to date—a group so rare that only about 1 in 6 million people worldwide belong to it, making María's life trajectory an invaluable sample for aging biology research.

 

When it comes to aging, many people associate longevity with longer telomeres—the "protective caps" at the ends of chromosomes that naturally shorten with age, and abnormally short telomeres are often linked to age-related diseases. However, María's test results challenged this perception: her average telomere length was shorter than that of all healthy volunteers, even reaching an "extremely shortened" state. What was more unusual was that this extreme telomere shortening did not expose her to disease—she remained free of age-related illnesses like cancer and Alzheimer's until the end of her life, with only mild hearing loss and mobility issues. The research team speculates that this "short telomere advantage" may have contributed to her cancer-free longevity: excessively short telomeres limit the unlimited proliferation of malignant cells, fundamentally reducing cancer risk. This finding breaks the inherent belief that "longer telomeres mean longer life," proving that telomere shortening is merely a "clock marker" of aging, not a direct "culprit" of disease. A similar "aging paradox" has been observed in other supercentenarians. For example, among 32 supercentenarians aged 110–119 studied by Boston University, despite showing aging signs like telomere shortening and immune cell senescence, only 2 (6%) had a history of myocardial infarction, 4 (13%) had experienced a stroke, and 8 (25%) had a history of cancer (all of which were cured). These figures are far better than those for the average 70-year-old population, which has a 15% myocardial infarction rate, 20% stroke rate, and over 40% cancer incidence. Clearly, the longevity of supercentenarians does not mean "no aging," but rather "separation of aging and disease."

 

María's multi-omics analysis revealed that her body simultaneously exhibited "signs of aging" and "protective mechanisms"—a common feature among supercentenarians worldwide. In terms of aging signs, her immune system showed "senescence signals": the activity of inflammation-related immune cells increased, and the B lymphocyte population expanded abnormally (a common sign of immune decline in the elderly). However, a series of "protective features" built a health barrier for her. Whole-genome sequencing found that she carried multiple "anti-aging gene variants": the DSCAML1 variant enhances immune cells' ability to recognize abnormal cells and protects nerve cells to maintain cognition; the LRP1/2 variants promote the clearance of excess cholesterol and amyloid proteins in the blood, preventing vascular sclerosis and dementia. More importantly, she had no harmful variants associated with diseases like Alzheimer's or diabetes. A study in the Italian journal GeroScience also confirmed that 82% of supercentenarians carry at least one gene variant that protects against cardiovascular disease or supports immunity, and their carrier rate of the APOEε4 allele (a risk gene for Alzheimer's) is 0—far lower than the 15% rate in the general population. Additionally, her lipid metabolism efficiency was comparable to that of a middle-aged person: her high-density lipoprotein cholesterol (HDL-C, "good cholesterol") reached 72 mg/dl (the healthy standard for women is >50 mg/dl), and her very low-density lipoprotein cholesterol (VLDL-C) was only 6 mg/dl, allowing efficient clearance of lipids that damage blood vessels. Her inflammation level was also in a "young state": the inflammatory marker GlycA was 621 μmol/l (a value <650 μmol/l is considered healthy), while 70% of average elderly people have elevated GlycA levels, and only 13% of the 32-person supercentenarian cohort had abnormal levels. This low-inflammatory state allowed her to successfully overcome COVID-19 at the age of 113, making her Spain's oldest COVID-19 survivor. Her gut microbiota also showed "youthful" characteristics: the content of Bifidobacterium (a key microbe for maintaining intestinal immune balance) was three times that of the average elderly person, while the pro-inflammatory Clostridium was significantly reduced. This feature is also observed in Italian supercentenarians; studies have confirmed that Bifidobacterium inhibits inflammation by producing short-chain fatty acids and regulates systemic immunity, making it a key factor in supercentenarians' "low disease incidence."

 

According to rDNA methylation clock assessment, María's biological age was 23 years younger than her chronological age. Coincidentally, in another study, the average epigenetic age of 184 centenarians/supercentenarians was 18 years younger than their actual age, and the age gap was generally over 20 years for those aged 110 and above. The key to this "clock slowdown" lies in the high methylation of repetitive DNA sequences (such as LINE-1 and ALU), as stable methylation levels prevent genomic instability. In contrast, the methylation of such sequences in average elderly people decreases significantly with age, directly accelerating cellular senescence. Manel Esteller's team also found that María's histone H3K79 methylation level was 40% higher than that of the average 70-year-old—this modification maintains the loose structure of DNA, ensuring the normal expression of cell repair genes. Additionally, the methylation state of ribosomal DNA (rDNA) remained stable, avoiding accelerated cellular senescence caused by abnormal ribosomal function. These epigenetic features act like "slowdown valves" for cells, making the aging rate of her bodily functions much slower than her chronological age.

 

While genes and epigenetics laid the foundation for María's longevity, her lifestyle habits further amplified these advantages—and these habits are highly consistent among supercentenarians worldwide. She maintained a habit of drinking 3 cups of yogurt daily for nearly 50 years; each cup contained Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus, probiotics that nourish the high levels of Bifidobacterium in her gut. An Italian study on supercentenarians found that 70% of them consume fermented foods at least 5 times a week, resulting in a significantly higher proportion of beneficial gut bacteria than the general population. For ordinary people, there is no need to imitate the "3 cups a day" routine—consuming 1 cup of yogurt with active probiotics, a small portion of natto, or kimchi daily for 3 months can increase the proportion of beneficial gut bacteria by 20%–30% and reduce inflammation levels by 10%–15%. Her daily diet centered on vegetables, fish, olive oil, and whole grains, with minimal intake of high-sugar, high-fat processed foods. Among the 32-person supercentenarian cohort studied in the US, 68% maintained a similar diet; those who ate deep-sea fish (rich in Omega-3 fatty acids) at least 3 times a week had HDL-C levels 12 mg/dl higher than those who did not. This dietary pattern optimizes lipid metabolism and reduces blood vessel damage—for the general population, adhering to it for 5 years can lower the risk of cardiovascular disease by 25%. Regular social interaction and a positive mindset were also indispensable. María participated in community handicraft activities even after turning 100, video-chatted with her family daily, and could clearly recall details of her move from San Francisco to Spain at the age of 8. This aligns with the findings of a study in the journal Brain, Behavior, & Immunity - Health, which analyzed 2,117 adults and found that "cumulative social advantage" (family relationships, community participation, emotional support) significantly slows epigenetic aging, reducing the DunedinPACE clock (a dynamic indicator of aging rate) by 12%. Among Italian supercentenarians, 85% maintain social interaction at least 3 times a week, and their cortisol levels are 15%–20% lower than those with little social contact. Excessively high cortisol levels accelerate abnormal DNA methylation, leading to faster aging.

 

Research confirms that advanced age and poor health are not inevitably linked—aging and disease can be distinguished at the molecular level. For ordinary people, there is no need to rely on "genetic luck"; María's habits of eating yogurt, following a Mediterranean diet, and maintaining regular social interaction are all replicable choices. In the future, as supercentenarian sample banks expand and research on aging mechanisms deepens, targeted anti-aging interventions may become a reality. However, the path to healthy longevity is already clear: accumulate "anti-aging capital" through small daily actions like healthy eating and socializing, and strive for the ultimate goal of "living independently and happily beyond 100."

Smart Laziness: The Invisible Key to Ord

Smart Laziness: The Invisible Key to Ordinary People's Counterattack 

Have you ever thought that all human inventions are deeply tied to "laziness" — the desire to avoid walking led to the invention of cars, the reluctance to wash dishes gave birth to dishwashers, and the aversion to manual calculation resulted in computers... This kind of "laziness" is an innovative gene driving civilization forward; and when it comes to the life and growth of ordinary people, "smart laziness" is a breakthrough code that is a million times more important than "blind diligence".

 

Many people equate "laziness" with idleness, but the kind of "laziness" that truly drives progress is a resistance to meaningless waste. Humans invented washing machines not because they hated labor, but because they didn't want to waste time on the repetitive mechanical action of scrubbing clothes; food delivery apps were created not because people were too lazy to cook, but to free up the time spent on buying ingredients and cooking for more valuable things. This kind of "laziness" is essentially a rebellion against "inefficient models" — it forces us to think: Is there a better path? Can tools replace redundant labor? Just like Henry Ford invented the assembly line not because he was too lazy to manage production, but because he wanted to "lazily" stop workers from doing meaningless repetitive handling, ultimately making large-scale car production possible.

 

You must have met such people around you: they are busy from morning till night, working overtime at work and staying up late to do side hustles after work, yet they still can't save money or see any hope of promotion. They use "diligence" as a fig leaf, but never think about whether their diligence is invested in the wrong place. For example, some people spend two hours haggling in the vegetable market to save a few dollars, but are unwilling to spend half an hour learning about financial management; some people insist on manually organizing reports late into the night, but never consider learning a data tool to generate them with one click; some people repeat mechanical work day after day, but never want to spend time improving their core skills... This kind of "foolish diligence" is essentially using physical busyness to avoid mental thinking, and ultimately getting deeper and deeper into an ineffective cycle.

 

True "smart laziness" is using the minimum energy cost to achieve the maximum results. For office workers, it means spending time polishing reusable work methods (such as creating a templated report or sorting out standardized processes) to "lazily" avoid repeating energy consumption for similar tasks. For entrepreneurs, it means using tools and systems to replace manual labor (such as using automated software to handle customer service or managing teams with SOPs) to "lazily" avoid getting stuck in trivial matters. For ordinary people, it means focusing on "high-value areas" — instead of dabbling in ten things, it's better to "lazily" avoid spreading energy and focus on doing one thing to the extreme. Just like those who succeeded by "laziness": some people were "too lazy" to keep accounts manually and developed a popular accounting app; some people were "too lazy" to cook every day and successfully started a business by developing pre-made meal recipes... Their "laziness" is a rejection of "inefficient diligence" and an embrace of "high-leverage effort".

 

From human civilization to personal growth, "laziness" has never been a derogatory term, but a wise choice — rejecting meaningless waste and investing energy in what truly creates value. So, next time, don't feel guilty about "slacking off". Try to ask yourself: Is there a more efficient way to do this? Am I engaging in "pseudo-diligence"? Learn to be smartly "lazy", and you will find that growth and counterattack can be so "easy".

AI Monetization: From Smart Assistants t

AI Monetization: From Smart Assistants to Commercial Link Entries, Exploring the Diverse Profit Models of AI

 

When ChatGPT partnered with Walmart, allowing users to complete orders and payments directly within the chat interface, we clearly saw a new breakthrough in AI profit models—smart assistants are evolving from "information interaction tools" to "commercial link entries". This "linking" monetization idea is just the tip of the iceberg in the AI profit ecosystem. From tool charging to scenario empowerment, AI's profit logic is expanding in multiple ways.

 

The most direct AI profit model still focuses on the excavation of "tool value". Take various smart assistants as an example, basic functions are free to attract users, while advanced functions (such as multi-turn complex conversations, professional field models) adopt a subscription-based charging model. Similar to ChatGPT's Plus membership and the "professional version" packages of domestic AI assistants, they all follow this logic—using continuous function iteration and experience upgrading to make users pay for "smarter tools".

 

As shown in the cooperation between ChatGPT and Walmart, AI is becoming a "super intermediary" in consumer scenarios. When users ask "What discounted products does Walmart have this week" in a chat, AI can not only give recommendations but also directly guide them to complete the order and payment. This "consultation-decision-consumption" closed loop transforms AI from an "information provider" to a "transaction facilitator", and platforms can profit through commissions, revenue sharing, and other methods. Beyond retail, fields such as finance and education are also replicating this logic: AI financial assistants recommend financial products and get a share, AI education assistants connect with course registrations and get customer acquisition shares... The more vertical the scenario, the higher the accuracy of monetization.

 

The profit potential of AI is also reflected in "derivative value". On the one hand, frequently used smart assistants can accumulate user behavior data. After desensitization and analysis, this data can be fed back to enterprises for product optimization and user operation (of course, data compliance must be strictly followed). On the other hand, AI capabilities can be "modularly output". For example, encapsulating an AI model in a certain field into an API and providing it to third-party developers or enterprises for use, while charging technical service fees. This "water-selling" profit model allows AI to play a more underlying role in the ecosystem and obtain continuous revenue sharing.

 

From the "single-point breakthrough" of tool charging, to the "link opening" of scenario monetization, and then to the "value cycle" of ecological derivation, AI's profit model is becoming more and more three-dimensional. When smart assistants are "linking" one after another, what we see is not only a business cooperation but also a key leap of AI from a "technical concept" to a "profitable entity". In the future, whoever can more closely bind AI capabilities with real business scenarios will seize the opportunity in the wave of AI monetization.

La paresse : le moteur insoupçonné du pr

La paresse : le moteur insoupçonné du progrès humain 

 

Dans la sagesse conventionnelle, la « paresse » est souvent un terme péjoratif. Mais avez-vous déjà pensé que c'est précisément la « paresse » ancrée dans la nature humaine qui est devenue la force motrice principale propulsant la civilisation vers l'avant ? Des outils de transport aux appareils intelligents, des gadgets ménagers à la Révolution industrielle, en remontant à leurs origines, de nombreuses inventions et créations ont débuté par le subtil désir humain de « prendre des raccourcis ».

 

Personne ne veut faire de longs trajets dans la boue ou sous le soleil brûlant, c'est pourquoi les humains ont inventé la roue. Des premiers chariots à roues en bois aux calèches, puis aux trains à vapeur et aux voitures à moteur à combustion interne, chaque itération du transport est motivée par la « paresse » de « ne pas vouloir marcher » et de « vouloir aller plus vite ». Plus tard, jugeant le transport terrestre insuffisamment rapide, la « paresse » a donné naissance aux avions. Les frères Wright n'ont pas inventé les avions parce qu'ils aimaient voyager ; très probablement, ils ont trouvé que voyager à travers les océans en bateau ou en train prenait trop de temps, alors ils ont simplement permis aux humains de « grandir » des ailes pour naviguer à travers les nuages d'une manière « paresseuse ». Aujourd'hui, le développement de la technologie aérospatiale est également, dans un sens, le fait que les humains veulent être « plus paresseux » — ne pas vouloir être confinés à la Terre et vouloir explorer l'univers.

 

Si tout le monde aimait les conversations en face-à-face, d'où viendraient les téléphones, les portables et les réseaux sociaux ? Dans les premiers temps, les gens communiquaient par lettre, et le processus d'attente était trop « torturant », c'est pourquoi le téléphone a été inventé. Mais tenir un combiné pour parler n'était toujours pas « paresseux » assez, c'est pourquoi les portables sont apparus. Maintenant, WeChat et les appels vidéo nous permettent de discuter avec des gens à des milliers de kilomètres tandis que nous sommes allongés, et même d'organiser des « rassemblements en ligne » avec un groupe de personnes en même temps. Ce genre de « paresse » a brisé les chaînes de l'espace et augmenté l'efficacité de la transmission de l'information de manière exponentielle.

 

Qui veut se battre avec des assiettes grasses après un repas ? L'invention du lave-vaisselle est un triomphe de la « paresse ». De même, les robots aspirateurs nous sauvent de se pencher pour balayer le sol, les machines à laver automatiques éliminent le souci du lavage à la main, et les cuiseurs à riz font de la cuisson du riz une tâche à un seul bouton… Ces « gadgets paresseux » nous libèrent des tâches ménagères fastidieuses, nous permettant d'avoir plus de temps pour faire ce que nous voulons vraiment — lire, voyager et passer du temps avec la famille. N'est-ce pas une amélioration de la qualité de vie ?

 

En fait, la « paresse » n'est jamais une question de passivité ou d'oisiveté ; c'est la quête humaine d'une vie « plus pratique, plus efficiente et plus confortable », une sagesse innovante cachée. Elle nous pousse à nous demander constamment : Y a-t-il une méthode plus simple ? Y a-t-il un outil plus économe en effort ? C'est ce genre de « paresse » qui favorise l'innovation technologique et le progrès social, permettant à la civilisation humaine de se diriger vers un avenir plus vaste grâce à des tentatives « paresseuses » répétées. Alors, la prochaine fois, n'ayez pas honte d'admettre votre « paresse ». Peut-être que votre prochaine idée « paresseuse » sera le point de départ de la prochaine percée de la civilisation !

The World is a "Ramshackle Crew": Don’t

The World is a "Ramshackle Crew": Don't Overestimate Complexity, Don't Fear Imperfection

 

Have you ever had a moment when you thought the operation of a certain field was as precise as a Swiss watch, only to find out it's more like a "ramshackle crew" — beneath the seemingly high-end surface, there are makeshift logics and flustered patches everywhere.

 

In fact, the world itself is a huge ramshackle crew, and the operation of many things is far less "high-end" than we imagine.

 

The backend of a top-tier game may not be a "temple of black technology", but a pile of garbage code dubbed "mountains of crap" by programmers. It may be written sloppily and have a chaotic structure, but with countless temporary patches and the idea of "just make it run first", it manages to support the hustle and bustle of millions of players online at the same time. Just like those AAA games that make you addicted, their underlying architecture may hide countless compromises that "work but are not elegant".

 

Behind a stunning performance, it's not all about "the elegance of precise rehearsal". The directing team may have been struggling with the lighting positions the day before, and the connection of a certain segment during the performance relies on a temporary gesture from the stagehand and an improvisation from the actor to save the day. The stage that seems smooth and seamless to the audience is underpinned by countless "flustered makeshifts".

 

Even a blockbuster article that makes you applaud is not necessarily the result of "inspired fluency". The author may have struggled with the topic for a long time, revised the opening ten times, and had to rely on researching materials and finding cases to bolster the content midway. In the end, its completion is somewhat driven by the idea of "first make the point clear, then think about whether it's brilliant".

 

The interesting thing about the world is this: it never runs according to a "perfect script", but instead,through countless "ramshackle-style makeshifts", it has created a prosperous scene.

 

So, stop being intimidated by the "myth of high-end". If you want to make a product, don't wait for the code to be perfect before launching it; if you want to hold an event, don't wait for the plan to be foolproof before starting it; if you want to write something, don't wait for inspiration to burst before putting pen to paper.

 

Accept the nature of the world as a "ramshackle crew", start first, try first, and "push forward with makeshifts". You will find that many things are not as difficult as you think; in many fields, you will realize that "everyone is a master of making do" once you get started.

 

After all, in this world that's like a "ramshackle crew", daring to "start with makeshifts" is much more reliable than "waiting for perfection to arrive".

AI Acting? Vidu's New Model Q2: Breakthr

AI Acting? Vidu's New Model Q2: Breakthroughs in Emotion and Action, Redefining AI Character Expressiveness

 

When AI can not only chat and write code but also act, would you exclaim, "Is this still the AI I know?" The newly released Q2 model by Vidu not long ago brings such a surprise—it can now portray characters like a professional actor, with delicate and appropriate expressions of various emotions, and the smoothness of action scenes has also achieved a qualitative leap compared to before.

 

In the development history of AI, "emotional expression" and "action simulation" have always been two major challenges. But the emergence of Vidu Q2 allows us to see breakthrough progress in AI's character shaping. It can accurately convey joy, anger, sadness, and happiness: the lonely eyes when sad, the stretching limbs when happy, and even the progressive layers of complex emotions can all be presented through the model's rendering. In terms of action scenes, whether it's the control of the strength of fists and feet or the coherence and rhythm of movements, it has improved significantly compared to previous AI models. It is no longer a stiff "mechanical movement" but carries real power and smoothness.

 

This makes people think about what the breakthrough in AI's "acting skills" means. In the field of film and television creation, it may become a creative assistant for screenwriters and directors, quickly presenting the emotional and action prototypes of characters. In the field of virtual idols, these delicate expressive abilities can make virtual characters more "vivid" and establish a stronger emotional connection with fans. Even in the gaming industry, the interactive experience of NPCs will become more immersive due to the upgrade of AI's emotions and actions.

 

From a tool that can only execute instructions to an "actor" that can perform emotions and complete action scenes, the evolution speed of Vidu Q2 is amazing. We have reason to look forward to how many "beyond cognition" surprises future AI will bring in fields such as content creation and virtual interaction.

CBASS: Yale University's Super "Decoder"

CBASS: Yale University's Super "Decoder" Unravels the Mysteries of Cortical Electrical Signals

 

From Yale University comes a groundbreaking method called CBASS, a super "decoder" that is revolutionizing our understanding of the brain. It has the remarkable ability to dissect the seemingly chaotic electrical signals in the cerebral cortex with extremely high temporal precision.

 

The electrical signals in the cerebral cortex are the "language" of brain activity, yet they are complex and fleeting, posing long-standing challenges for scientists in their analysis. CBASS emerges as a high-performance signal analysis tool for researchers. It can capture the subtle temporal differences in cortical electrical signals, dissecting what was once seemingly disorganized electrical activity with precise temporal resolution. This allows us to see the "real-time computation" process of the brain when it processes information and generates cognition.

 

Imagine when we think about a problem or have a thought, the neurons in the cerebral cortex generate a series of electrical signal pulses. CBASS is like a high-speed camera, accurately recording and decoding the order and interval duration of these pulses. It helps us understand "how the brain completes thinking, decision-making, and perception on a millisecond time scale." This is revolutionary for understanding the pathogenesis of cognitive disorders and neurological diseases, and even for developing more precise brain-computer interface technologies.

 

Researchers might have initially thought that what they would see after decoding with CBASS would be a "linear" signal logic. However, in actual exploration, it may lead us to discover more complex and exquisite interaction patterns in the brain's signal network. Each precise dissection of cortical electrical signals is a deep exploration of the brain's intelligence, and the emergence of CBASS undoubtedly makes this exploration more efficient and profound.

 

It is foreseeable that as CBASS technology continues to improve and be applied, our understanding of the brain will undergo a new leap. Those ultimate mysteries about consciousness, thinking, and memory may gradually come to light with the help of this super "decoder" from Yale University.

La paresse intelligente : la clé invisib

La paresse intelligente : la clé invisible de la reconquête des gens ordinaires 

 

Avez-vous déjà pensé que toutes les inventions humaines sont profondément liées à la « paresse » — le fait de ne pas vouloir marcher a mené à l'invention des voitures, le refus de laver la vaisselle a donné naissance aux lave-vaisselles, et l'aversion pour le calcul manuel a abouti à la création des ordinateurs… Ce genre de « paresse » est un gène d'innovation qui pousse la civilisation en avant ; et quand il s'agit de la vie et de la croissance des gens ordinaires, la « paresse intelligente » est un code de percée qui est un million de fois plus important que la « diligence aveugle ».

 

Beaucoup de gens assimilent la « paresse » à la paresse, mais le genre de « paresse » qui pousse véritablement le progrès est une résistance au gaspillage sans objet. Les humains ont inventé les machines à laver non pas parce qu'ils haïssaient le travail, mais parce qu'ils ne voulaient pas perdre de temps sur l'action mécanique répétitive de gratter les vêtements ; les applications de livraison de repas ont été créées non pas parce que les gens étaient trop paresseux pour cuisiner, mais pour libérer le temps passé à acheter des ingrédients et à cuisiner pour des choses plus valables. Ce genre de « paresse » est essentiellement une rébellion contre les « modèles inefficaces » — il nous force à penser : Y a-t-il un meilleur chemin ? Les outils peuvent-ils remplacer un travail redondant ? Tout comme Henry Ford a inventé la chaîne de montage non pas parce qu'il était trop paresseux pour gérer la production, mais parce qu'il voulait « paresseusement » empêcher les ouvriers de faire des manipulations répétitives sans objet, permettant enfin une production de voitures à grande échelle.

 

Vous avez sûrement rencontré ce genre de personnes autour de vous : elles sont occupées du matin au soir, travaillent en heures supplémentaires au travail et font des travaux à temps partiel la nuit après le travail, mais elles ne peuvent toujours pas économiser d'argent ni voir d'espoir de promotion. Elles utilisent la « diligence » comme un paravent, mais ne pensent jamais si leur diligence est investie au mauvais endroit. Par exemple, certaines personnes passent deux heures à marchander sur le marché pour économiser quelques dollars, mais ne veulent pas passer une demi-heure à s'informer sur la gestion financière ; certaines personnes insistent pour organiser manuellement des rapports tard dans la nuit, mais ne considèrent jamais apprendre un outil de données pour les générer en un seul clic ; certaines personnes répètent des travaux mécaniques jour après jour, mais ne veulent jamais passer du temps à améliorer leurs compétences de base… Ce genre de « diligence bête » consiste essentiellement à utiliser l'occupation physique pour éviter la réflexion mentale, et finit par s'enfoncer de plus en plus dans un cycle inefficace.

 

La véritable « paresse intelligente » consiste à utiliser le coût d'énergie minimum pour obtenir les résultats maximaux. Pour les salariés, cela signifie passer du temps à polir des méthodes de travail réutilisables (comme créer un rapport modélisé ou élaborer des processus standardisés) pour « paresseusement » éviter de répéter la consommation d'énergie pour des tâches similaires. Pour les entrepreneurs, cela signifie utiliser des outils et des systèmes pour remplacer le travail manuel (comme utiliser un logiciel automatisé pour gérer la relation client ou gérer des équipes avec des procédures standardisées) pour « paresseusement » éviter de se retrouver coincé dans des questions triviales. Pour les gens ordinaires, cela signifie se concentrer sur les « domaines à haute valeur » — au lieu de s'essayer à dix choses, il vaut mieux « paresseusement » éviter de disperser son énergie et se concentrer sur une seule chose pour la pousser à l'extrême. Tout comme ceux qui ont réussi grâce à la « paresse » : certaines personnes étaient « trop paresseuses » pour tenir leurs comptes manuellement et ont développé une application de comptabilité populaire ; certaines personnes étaient « trop paresseuses » pour cuisiner tous les jours et ont réussi à créer une entreprise en développant des recettes de plats préparés… Leur « paresse » est un rejet de la « diligence inefficace » et un embrassement de l'« effort à haut potentiel ».

 

De la civilisation humaine à la croissance personnelle, la « paresse » n'a jamais été un terme péjoratif, mais un choix judicieux — rejeter le gaspillage sans objet et investir son énergie dans ce qui crée véritablement de la valeur. Alors, la prochaine fois, ne vous sentez pas coupable de « ralentir ». Essayez de vous demander : Y a-t-il une manière plus efficace de faire cela ? M'engage-t-je dans une « fausse diligence » ? Apprenez à être « paresseux » de manière intelligente, et vous verrez que la croissance et la reconquête peuvent être si « faciles ».

Decoding Goth Rock: From Its First Track

Decoding Goth Rock: From Its First Track to Its Style, Understanding the Musical Code of Dark Aesthetics

 

When you hear the term "Goth," you might think of castles, vampires, and dark-hued romance—but when this aesthetic collides with rock, it gives birth to the highly distinctive genre of Goth Rock. It is not merely "dark music," but a complete stylistic system that has carried a unique sense of narrative and atmosphere since its inception. Today, we'll trace the key threads of Goth Rock, from its "origins" to its "core."

 

The world's first Goth Rock song is still universally recognized as Bela Lugosi's Dead, released in 1979 by the British band Bauhaus. This over-9-minute track set the tone for Goth Rock outright: with its slow, deep bassline, faint distorted guitar, ethereal yet cold vocals, and lyrics centered on the death of horror film star Bela Lugosi (famous for playing Count Dracula), it brought "dark aesthetics" into music. Unlike the aggression of punk, it used a more lingering atmosphere to formally root "Goth" in the rock scene—transcending its earlier ties to literature and visual art.

 

The lyrics of Bela Lugosi's Dead are themselves a Gothic poem. Centered on Bela Lugosi's funeral, they paint eerie yet ornate death scenes with lines like "White on white translucent black capes / Back on the rack" and "Black coffins lying in red velvet lined / Lids." Imagery such as "Bats have left the bell tower" and "Victims have been bled" echoes Lugosi's vampire roles; the repeated chant of "Undead, undead, undead" is the finishing touch—it not only alludes to the immortality of vampires but also symbolizes how Lugosi's image lives on forever in culture through his work. The lyrics carry no intense emotion, yet stack fragmented scenes to create a "cold romance"—a template that would define subsequent Goth Rock lyrics.

 

If Bela Lugosi's Dead is the "starting point" of Goth Rock, its musical style forms the "backbone" of this aesthetic. The core style of Goth Rock is essentially a fusion of "dark atmosphere" and "musical texture," which can be broken down into three key dimensions:

First, in instrumentation and arrangement: unlike punk, which relies on intense rhythms for impact, Goth Rock uses a "slow yet heavy" texture to build atmosphere. Distorted guitars have a soft yet grainy tone; basslines are thick and prominent throughout; drumbeats are steady and slow. Piano, synths, or strings are even added in some works, layering a more ornate, somber undertone.

Second, in vocals and melody: vocalists rarely use high, powerful singing; instead, they favor deep, ethereal, even mournful voices. Melodies are mostly slow, winding minor-key lines, avoiding bright major keys—creating a listening experience that feels like "wandering slowly in darkness," inherently melancholic.

Third, in themes and atmosphere: lyrics always revolve around death, loneliness, religious metaphors, and Gothic literary imagery (e.g., castles, vampires, broken love). The overall pursuit is "dark romance"—not horror, but beauty that shines through melancholy. Just like Bela Lugosi's Dead, it uses death narratives to tell an alternative story of "eternity."

 

Today, when we talk about Goth Rock, it is no longer a niche music genre but an aesthetic symbol that has seeped into fashion, film, literature, and more. Yet looking back to its roots—from Bauhaus' Bela Lugosi's Dead to its unique musical style—we can see that the core of Goth Rock was never about "trying to be cool." Instead, it uses a dark exterior to carry reflections on "loneliness," "death," and "eternity"—and that is perhaps why it has endured for decades, still captivating those who crave a unique aesthetic.

New Insight into the Antithrombotic Mech

New Insight into the Antithrombotic Mechanism of Berberine: The Wisdom of Natural Drugs in Gut Microbiota Metabolism

 

A breakthrough in the mechanism of berberine, a natural drug, in antithrombosis has been achieved. This study reveals for the first time that berberine exerts its antithrombotic effect by reshaping the gut microbiota. It can promote the gut microbiota to accelerate the degradation of the harmful metabolite "phenylacetic acid", thereby reducing the production of the prothrombotic substance "phenylacetylglycine" and blocking the pathway of thrombus formation from the metabolic source.

 

This discovery closely links the mechanism of action of natural drugs with the gut microbiota metabolic network, demonstrating the unique value of berberine in the field of antithrombosis. It is no longer a simple component effect, but achieves thrombus prevention at the metabolic level by regulating the intestinal microecology, opening up a new perspective for the research of natural drugs.

 

For the prevention and treatment of thrombotic diseases, the clarification of this mechanism is of great significance. It suggests that in the future, more precise thrombus prevention and treatment strategies may be developed from the perspective of gut microbiota regulation and metabolite intervention. As a representative of natural drugs, berberine is also expected to play an important role in this, bringing safer and more targeted treatment options for patients.

Asymmetric Growth of Life Abilities: Bey

Asymmetric Growth of Life Abilities: Beyond Fluid Intelligence, the Capability Advantages of Middle Age Are Shining

 

We often assume that the peak of intelligence belongs only to the young, but the truth is far from that. Although fluid intelligence, such as reasoning speed and memory, which relies on physiological foundations, indeed reaches its peak in youth, the map of human abilities is far more than just this single dimension. Many key abilities, such as emotional intelligence, moral judgment, and financial decision-making ability, shine more brightly in middle age, demonstrating the "asymmetric growth" of life abilities.

 

Middle age is a golden period where life experience and cognitive depth intersect. Emotional intelligence becomes increasingly mature during this stage. Middle-aged people can perceive their own and others' emotions more accurately. In complex interpersonal and workplace environments, they can properly handle conflicts and coordinate all parties with their delicate emotional management abilities. Moral judgment also becomes more profound due to the accumulation of years. Having experienced various trials in life, middle-aged people have a more three-dimensional understanding of right and wrong, good and evil, and ethical morality. The judgments they make often take into account both principles and reality, full of humanistic care.

 

In terms of financial decision-making ability, middle-aged people also show unique advantages. They have experienced different economic cycles, accumulated rich financial experience, and are more rational in weighing risks and returns. In financial behaviors such as investment and consumption, they can make decisions that are more suitable for their own situation and long-term. The improvement of this series of abilities is not accidental, but an inevitable result of the multiple roles of life experience, social experience, and self-reflection in middle age.

 

Therefore, the growth of life abilities is not a one-way downhill road. The decline of fluid intelligence does not mean an overall decline in abilities. The rise of abilities in areas such as emotion, morality, and financial decision-making in middle age makes each stage of life have unique value and advantages. It also allows us to see that each stage of life has its irreplaceable ability highlights.

The "Architects" of Tooth Regeneration:

The "Architects" of Tooth Regeneration: How CXCL12 is Reshaping the Future of Tooth Roots

 

In the field of dental health, a group of hidden "architects" are quietly rewriting the possibilities of tooth regeneration—they are cells with a unique marker, CXCL12, dubbed "tooth root architects" by scientists, tasked with building the core foundation of teeth.

 

The health and stability of teeth lie in the strength of their roots. The existence of these "tooth root architects" brings new hope for tooth regeneration. Their core mission is to build the most essential foundation of teeth, meaning that once we can deeply understand and utilize their working mechanisms, we may achieve breakthroughs in the treatment of tooth damage and root lesions.

 

Imagine when teeth suffer root damage due to trauma, severe tooth decay, or periodontal disease, these "architects" can be guided and activated to rebuild healthy root structures at the affected sites. This is no longer just simple tooth filling or denture fitting, but a natural "rebirth" of teeth from the root, restoring their natural function and stability.

 

Currently, research on CXCL12 and "tooth root architects" is still advancing. Scientists are committed to unraveling their specific mechanisms in root development and regeneration, exploring how to use biological regulatory methods to make these "architects" exert their power precisely when needed to complete root repair and reconstruction.

 

This research direction not only opens up a new path for regenerative dental medicine but also reveals the enormous potential of the body's own repair capabilities. Perhaps in the near future, when we face damage to the tooth roots, we will no longer need to rely on external dentures or implants. Instead, we can leverage the power of these "tooth root architects" to enable natural tooth regeneration and regain a set of healthy and strong native teeth.

The Wisdom of "Subtraction" in the Secon

The Wisdom of "Subtraction" in the Second Half of Life: How to Embrace Calm by Simplifying Life After 50

 

At different stages of life, the rhythm and focus of life should naturally adjust. Especially when people enter their 50s, a piece of advice is increasingly recognized by more people: by dealing with large items, simplifying finances, and organizing life order, we can perform a "subtraction operation" for the second half of life and move towards a more relaxed life with calmness and clarity.

 

When crossing the threshold of 50, you might as well start to sort out large items and simplify financial structures. The large furniture accumulated in life, electrical appliances that have not been used for a long time, or those "large items" that carry memories but take up space can be sorted and disposed of in a planned way, allowing the living space to return to cleanliness and transparency. Financially, it is also recommended to consolidate bank accounts. There is no need to hold too many bank cards. Managing a commonly used card centrally can not only reduce the energy consumption of management but also make the financial situation more clear and controllable.

 

By the age of 60, disposing of real estate and idle items can be put on the agenda. Those vacant properties and idle items that are not used all year round, instead of depreciating and gathering dust over time, can be properly disposed of according to their own needs and life plans, focusing energy and resources on things that can truly improve the quality of life.

 

When entering the 70s, gradually moving into a convenient living environment is a practical choice to "lighten the burden" of life. Choosing a residence with convenient transportation and complete facilities can reduce the trivial troubles of travel and life, make the later life more convenient and secure, and leave more time for the people and things you truly love.

 

This kind of "subtraction" life adjustment is not a compromise to life, but a clear wisdom. It allows us to get rid of redundant burdens in the second half of life, invest energy and effort in more valuable dimensions that can bring happiness, and finally gain abundance in simplicity and savor the true meaning of life in calmness.

New Discovery of Berberine, a Natural Dr

New Discovery of Berberine, a Natural Drug, in Antithrombosis: From Traditional Chinese Medicine Component to Intestinal Metabolism, a Scientific Breakthrough

 

Natural drug research has always been a hot topic in the medical field. Recently, a study focusing on berberine has revealed the new potential of this traditional Chinese medicine component in the field of antithrombosis. Berberine is the main bioactive component of traditional Chinese medicines such as Coptis chinensis, and its effects in antibacterial and anti-inflammatory aspects have been widely studied for a long time. This study, however, focuses on its role in thrombosis prevention and treatment.

 

The research team first established a carrageenan-induced mouse thrombosis model. Through experiments, it was found that berberine could significantly inhibit the formation of tail thrombosis in mice in a dose-dependent manner. This finding provides direct animal experimental evidence for the application of berberine in the treatment of thrombotic diseases and also allows us to see the possibility of natural drugs in the prevention and treatment of cardiovascular diseases.

 

To further explore the mechanism of berberine's antithrombotic effect, the researchers used untargeted metabolomics technology and finally identified a key gut microbiota-host co-metabolite—phenylacetylglycine. The experimental results showed that berberine could significantly reduce the plasma level of this metabolite. This discovery links the mechanism of berberine's action with the intestinal metabolic network, opening up a new perspective for us to understand the action pathway of natural drugs. It also suggests that gut microbiota metabolism may play an important role in the process of thrombosis formation.

 

From the active component in Coptis chinensis to the antithrombotic effect in animal models, and then to the mechanism exploration at the level of intestinal metabolism, the research journey of berberine not only shows the research depth of natural drugs but also provides new ideas for the prevention and treatment of thrombotic diseases. In the future, with the further development of research, berberine may play a more important role in clinical thrombosis treatment, bringing new hope to patients.

How to Choose a Statin? The Answer Lies

How to Choose a Statin? The Answer Lies in Individual Differences in Side Effects and Efficacy

 

When it comes to statins, many people ask, "Which one has the fewest side effects and the best efficacy?" In fact, there is no uniform answer to this question—statins exhibit significant individual differences in both side effects and efficacy. The selection must be comprehensively judged based on an individual's specific circumstances, and there is no "one-size-fits-all optimal solution" applicable to everyone.

 

From the perspective of side effects, different statins have distinct safety profiles. For example, pravastatin is not metabolized by the liver's CYP3A4 enzyme, which means it carries a relatively lower risk of drug interactions with other medications and has a smaller impact on the liver. It is suitable for people who need to take multiple drugs simultaneously or have sensitive liver function. On the other hand, while rosuvastatin and atorvastatin have outstanding lipid-lowering effects, some patients may experience side effects such as muscle pain and elevated liver enzymes. Additionally, rosuvastatin has certain requirements for renal function, and patients with impaired renal function need strict dosage adjustments. Overall, the incidence of overall side effects of moderate-to-low-intensity statins (such as pravastatin and simvastatin) is usually lower than that of high-intensity statins (such as atorvastatin and rosuvastatin). However, whether a specific individual can tolerate a drug still needs to be observed after they start taking it.

 

In terms of efficacy, the core function of statins is to lower low-density lipoprotein cholesterol (LDL-C, known as "bad cholesterol"), and different statins vary significantly in their lipid-lowering strength. Among them, rosuvastatin and atorvastatin are classified as high-intensity statins. At the same dosage, they reduce LDL-C to a greater extent, making them more suitable for patients who require a significant reduction in cholesterol—such as those with coronary heart disease or diabetes combined with hypercholesterolemia. In contrast, moderate-to-low-intensity statins like pravastatin, simvastatin, and pitavastatin have relatively mild lipid-lowering effects. They are more suitable for patients with mild cholesterol elevation or poor tolerance to high-intensity statins, such as the elderly and individuals with weak liver or kidney function.

 

It is particularly important to note that statins are prescription drugs and cannot be chosen arbitrarily based solely on "the number of side effects" or "the strength of efficacy." Doctors will comprehensively evaluate factors such as your lipid levels (especially the target value of LDL-C), underlying diseases (e.g., whether you have hypertension, diabetes, or coronary heart disease), concurrent use of other medications, age, and liver/kidney function to formulate an appropriate medication plan. During the medication period, it is also necessary to regularly recheck indicators such as liver enzymes and creatine kinase to promptly detect and address potential side effects, ensuring the safe and effective use of the drug.

Laziness: The Unsung Driver of Human Pro

Laziness: The Unsung Driver of Human Progress 

 

In conventional wisdom, "laziness" is often a derogatory term. But have you ever thought that it is precisely the "laziness" rooted in human nature that has become the primary driving force propelling civilization forward? From transportation tools to smart devices, from household gadgets to the Industrial Revolution, tracing back to the origins, many inventions and creations began with humans' subtle desire to "cut corners".

 

No one wants to trek long distances in mud or under the scorching sun, so humans invented the wheel. From the initial wooden wheel carts to carriages, then to steam-powered trains and internal combustion engine-driven cars, each iteration in transportation is driven by the "laziness" of "not wanting to walk" and "wanting to go faster". Later, finding ground transportation insufficiently fast, "laziness" gave birth to airplanes. The Wright brothers didn't invent airplanes because they loved traveling; most likely, they found traveling across oceans by ship or train too time-consuming, so they simply let humans "grow" wings to shuttle through the clouds in a "lazy" way. Today, the development of aerospace technology is also, in a sense, humans wanting to be "lazier" — not wanting to be confined to Earth and wanting to explore the universe.

 

If everyone enjoyed face-to-face chats, where would telephones, mobile phones, and social media come from? In the early days, people communicated by letter, and the waiting process was too "torturous", so the telephone was invented. But holding a receiver to talk was still not "lazy" enough, so mobile phones came into being. Now, WeChat and video calls allow us to chat with people thousands of miles away while lying down, and even have "cloud gatherings" with a group of people at the same time. This kind of "laziness" has broken the shackles of space and increased the efficiency of information transmission exponentially.

 

Who wants to struggle with greasy dishes after a meal? The invention of the dishwasher is a triumph of "laziness". Similarly, robot vacuum cleaners save us from bending over to sweep the floor, fully automatic washing machines eliminate the trouble of hand-washing, and rice cookers make cooking rice a one-button task... These "lazy gadgets" free us from tedious housework, allowing us to have more time to do what we really want — reading, traveling, and spending time with family. Isn't this an improvement in the quality of life?

 

In fact, "laziness" is never about passivity or idleness; it is humans' pursuit of a "more convenient, more efficient, and more comfortable" life, a hidden innovative wisdom. It drives us to constantly ask: Is there a simpler method? Is there a more labor-saving tool? It is this kind of "laziness" that promotes technological innovation and social progress, enabling human civilization to move toward a broader future through repeated "lazy" attempts. So, next time, don't be ashamed to admit your "laziness". Maybe your next "lazy" idea will be the starting point of the next breakthrough in civilization!

AI Trading Signals Meet Auto-Execution:

AI Trading Signals Meet Auto-Execution: This Tool Lets You Copy Top-Tier Trading Strategies with One Click

 

In today's era of deep integration between quantitative trading and AI technology, how can ordinary investors keep up with the pace of professional trading? The recent emergence of a tool may offer the answer—it can track strategies from AI trading signal platforms and automatically execute buy-and-sell operations in your trading account, making "copying successful trades" easily accessible.

 

The core capability of this tool first lies in its accurate tracking of AI trading signals from the nof1.ai platform. As a highly watched AI trading signal platform in the industry, nof1.ai aggregates numerous trading strategies based on big data and deep learning. This tool can capture these signals in real time, essentially "moving" the analytical results of professional teams directly in front of you.

 

More importantly, it supports users to configure their own Binance exchange API keys. This means your funds remain in your own account at all times; the tool only acts as an execution layer, automatically completing buy-and-sell operations on your behalf based on the captured AI signals. This not only ensures fund security but also realizes trading automation.

 

Once deployed and operational, this tool can automatically execute the exact same buy or sell actions as AI models like DeepSeek in your account. Imagine: when an AI model such as DeepSeek makes a trading decision based on market conditions, technical indicators, and other factors, you don't need to perform manual operations—the tool will synchronously execute the trade for you in real time, allowing you to keep up with the AI's response speed in the fast-changing trading market.

 

For ordinary investors, this is undoubtedly a powerful tool to lower trading thresholds and improve trading efficiency. You don't need to spend a lot of time researching the market or refining strategies; by simply using this tool, you can get on the fast track of AI trading and attempt to replicate those professional-level trading results in the wave of cryptocurrency trading. Of course, investing comes with risks—even AI strategies are not foolproof. Everyone should remain rational and conduct thorough risk assessments when using the tool.

Gothic Literature: Representative Works

Gothic Literature: Representative Works and Historical Development

 

Gothic literature emerged in late 18th-century Britain as a vital branch of Romantic literature. Centered on mysterious, horrifying, and supernatural elements, it focuses on the dark side of human nature and social repression, conveying a tense atmosphere through settings like ancient castles, ruins, and suspenseful plots. Its development history and representative works exhibit distinct阶段性 characteristics.

 

The origin of Gothic literature is generally marked by Horace Walpole's The Castle of Otranto (1764). This work, for the first time, combined medieval castle settings, supernatural events (such as a giant helmet falling from the sky), and family curses, establishing the basic framework of the "Gothic novel" and being regarded as the "founding work" of Gothic literature. From the late 18th century to the early 19th century, Gothic literature entered an early stage of development, with the emergence of several classic works: Ann Radcliffe's The Mysteries of Udolpho enhanced the sense of suspense and moral metaphors in Gothic literature through delicate psychological descriptions and the narrative pattern of the "rescued heroine"; Matthew Lewis's The Monk broke through traditions by incorporating more radical dark elements like religious fanaticism and devil's pacts, expanding the thematic boundaries of Gothic literature.

 

The 19th century was the golden age of Gothic literature. Works not only continued to thrive in Britain but also spread to many European and American countries, integrating deeply with realism and romanticism. British author Mary Shelley's Frankenstein (1818) is a milestone. Breaking away from traditional castle settings, it used the concept of a "humanoid created through scientific experiments" to combine Gothic horror with reflections on technological ethics and human alienation, endowing Gothic literature with profound philosophical connotations. Robert Louis Stevenson's Strange Case of Dr. Jekyll and Mr. Hyde (1886), through the dual-personality setting of "Dr. Jekyll and Mr. Hyde," visualized the theme of "the opposition between good and evil in human nature," becoming a classic of psychological Gothic. American literature also contributed important works during this period: the short stories of Edgar Allan Poe (such as The Fall of the House of Usher and The Black Cat) pushed the psychological horror of Gothic literature to its peak through delicate atmosphere creation and the extreme exploration of "death and madness," laying the foundation for the unique style of American Gothic literature. Nathaniel Hawthorne's The Scarlet Letter used the symbol of the "scarlet letter A" to combine Gothic-style moral anxiety with social criticism, set against the backdrop of religious oppression in the colonial era.

 

From the late 19th century to the 20th century and beyond, Gothic literature gradually broke through the form of traditional novels, expanding into diverse fields and forming the "Neo-Gothic" or "Post-Gothic" genre. Bram Stoker's Dracula (1897) created the classic Gothic image of "Count Dracula," integrating Eastern European folk tales with the social anxieties of the Victorian era. It became the origin of vampire-themed works and profoundly influenced later films, television, and literature. In the mid-to-late 20th century, Gothic elements penetrated into horror novels, fantasy literature, and even popular culture. For example, Anne Rice's The Vampire Chronicles series reconstructed vampire images, endowing them with emotional and human struggles. In contemporary times, works such as The Twilight Saga and Harry Potter have drawn on the mysterious settings and supernatural concepts of Gothic literature, allowing Gothic elements to integrate into popular culture in a more accessible way and sustaining the vitality of this literary genre.

Ant Group Publicly Releases Training Det

Ant Group Publicly Releases Training Details of Ling 2.0: Unveiling MoE Architecture, FP8 Training, and Multi-Stage Strategies

 

On October 25, 2025, Ant Group released a technical report on the arXiv platform, publicly disclosing the training details of its large language model, Ling 2.0, for the first time, providing the industry with a reference that combines technical depth and practical value. In terms of model architecture design, Ling 2.0 adopts a unified Mixture of Experts (MoE) basic architecture, configured with 256 routing experts, 8 active experts, and 1 shared expert, with an overall activation rate controlled at approximately 3.5%, ensuring both model performance and efficiency. Meanwhile, the architecture integrates the aux-loss-free load balancing strategy and Multi-Token Prediction (MTP) technology to further enhance the model's stability and prediction accuracy. Combined with the Ling scaling law to achieve precise extrapolation and expansion, it provides flexible support for the model's adaptation in different scenarios.

 

The pre-training phase is crucial for Ling 2.0 to build core capabilities. It relies on a high-quality dataset of over 20T tokens, covering fields such as common sense, code, mathematics, and multilingual content, ensuring the comprehensiveness and diversity of the model's knowledge system. A multi-stage strategy is adopted during the training process: first, general pre-training is completed on a large-scale general corpus to consolidate the model's basic language understanding and generation capabilities; then, mid-term training is conducted on a medium-scale, task-specific corpus to targeted enhance the model's adaptability in specific scenarios; at the same time, the context length is extended to 128K, significantly improving the model's ability to process long texts. In addition, the team innovatively introduced Chain of Thought (CoT) data to activate the model's logical reasoning ability in advance, laying a foundation for subsequent task performance optimization. The adoption of the WSM (Warm-up, Stabilization, Merging) scheduler, which replaces the traditional Learning Rate (LR) decay with checkpoint merging, makes the training process more efficient and stable.

 

In the post-training phase, Ling 2.0 continuously optimizes the model performance through methods such as separately trained supervised fine-tuning and evolutionary reasoning. Especially in the reinforcement learning phase, an innovative LPO (Linguistics-Unit Policy Optimization, LingPO) method is proposed. This method performs policy optimization at the "sentence" granularity, which is more in line with the expression logic of natural language and can effectively improve the coherence and rationality of the model's output. At the same time, the team also designed a hybrid reward mechanism of "Grammar-Function-Aesthetics", guiding the model from multiple dimensions such as language standardization, task practicality, and expression fluency, ensuring that the model's output not only meets functional requirements but also achieves a higher standard in terms of language quality.

 

Notably, Ling 2.0 has also achieved important breakthroughs in training infrastructure. It adopts FP8 mixed-precision training throughout the entire process, making it the largest known foundation model trained using FP8. This technical choice brings significant advantages: on the one hand, it greatly saves memory usage, making the training of larger-scale models possible; on the other hand, it supports more flexible parallel segmentation strategies, improving the utilization of hardware resources; finally, it achieves an end-to-end acceleration of over 15%, providing a new technical path for the efficient training of large models and valuable practical experience for the industry in optimizing large model training efficiency.